Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion

Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative contribution of UDP-glucose (UDP-G...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Parandeh, Fariborz, Amisten, Stefan, Verma, Gaurav, Mohammed Al-Amily, Israa, Dunér, Pontus, Salehi, Albert
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650237/
https://ncbi.nlm.nih.gov/pubmed/32855238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012929
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