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Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion
Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative contribution of UDP-glucose (UDP-G...
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| Izdano u: | J Biol Chem |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7650237/ https://ncbi.nlm.nih.gov/pubmed/32855238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012929 |
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