Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

A C9orf72 repeat expansion is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis. One of the suggested pathomechanisms is toxicity from dipeptide repeat proteins (DPRs), which are generated via unconventional translation of sense and antisense repeat tra...

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Detalles Bibliográficos
Publicado en:Acta Neuropathol Commun
Main Authors: Quaegebeur, Annelies, Glaria, Idoia, Lashley, Tammaryn, Isaacs, Adrian M.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650212/
https://ncbi.nlm.nih.gov/pubmed/33168090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01036-y
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