An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNe...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Roubroeks, Janou A.Y., Smith, Adam R., Smith, Rebecca G., Pishva, Ehsan, Ibrahim, Zina, Sattlecker, Martina, Hannon, Eilis J., Kłoszewska, Iwona, Mecocci, Patrizia, Soininen, Hilkka, Tsolaki, Magda, Vellas, Bruno, Wahlund, Lars-Olof, Aarsland, Dag, Proitsi, Petroula, Hodges, Angela, Lovestone, Simon, Newhouse, Stephen J., Dobson, Richard J.B., Mill, Jonathan, van den Hove, Daniël L.A., Lunnon, Katie
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649340/
https://ncbi.nlm.nih.gov/pubmed/32745807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.06.023
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