An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNe...

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Vydáno v:Neurobiol Aging
Hlavní autoři: Roubroeks, Janou A.Y., Smith, Adam R., Smith, Rebecca G., Pishva, Ehsan, Ibrahim, Zina, Sattlecker, Martina, Hannon, Eilis J., Kłoszewska, Iwona, Mecocci, Patrizia, Soininen, Hilkka, Tsolaki, Magda, Vellas, Bruno, Wahlund, Lars-Olof, Aarsland, Dag, Proitsi, Petroula, Hodges, Angela, Lovestone, Simon, Newhouse, Stephen J., Dobson, Richard J.B., Mill, Jonathan, van den Hove, Daniël L.A., Lunnon, Katie
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649340/
https://ncbi.nlm.nih.gov/pubmed/32745807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.06.023
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