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Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy

Pregnancy is a period of significant change that impacts physiological and metabolic status leading to alterations in the disposition of drugs. Uncertainty in drug dosing in pregnancy can lead to suboptimal therapy, which can contribute to disease exacerbation. A few studies show there are increased...

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Detalhes bibliográficos
Publicado no:NPJ Syst Biol Appl
Main Authors: George, Blessy, Lumen, Annie, Nguyen, Christine, Wesley, Barbara, Wang, Jian, Beitz, Julie, Crentsil, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648747/
https://ncbi.nlm.nih.gov/pubmed/33159093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-020-00157-3
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