Developmental programming: gestational testosterone excess disrupts LH secretion in the female sheep fetus

BACKGROUND: Prenatal testosterone (T) excess results in reproductive and metabolic perturbations in female sheep that closely recapitulate those seen in women with polycystic ovary syndrome (PCOS). At the neuroendocrine level, prenatal T-treated sheep manifest increased pituitary sensitivity to GnRH...

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Vydáno v:Reprod Biol Endocrinol
Hlavní autoři: Landers, Renata S. M., Padmanabhan, Vasantha, Cardoso, Rodolfo C.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648305/
https://ncbi.nlm.nih.gov/pubmed/33158439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12958-020-00667-z
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