Developmental programming: Prenatal Testosterone Excess Disrupts Pancreatic Islet Developmental Trajectory in Female Sheep

Prenatal testosterone (T)- treated female sheep manifest juvenile insulin resistance, post-pubertal increase in insulin sensitivity and return to insulin resistance during adulthood. Since compensatory hyperinsulinemia is associated with insulin resistance, altered pancreatic islet ontogeny may cont...

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Bibliographic Details
Published in:Mol Cell Endocrinol
Main Authors: Jackson, Ian J, Puttabytappa, Muraly, Anderson, Miranda, Muralidharan, Meha, Veiga-Lopez, Almudena, Gregg, Brigid, Limesand, Sean, Padmanabhan, Vasantha
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609617/
https://ncbi.nlm.nih.gov/pubmed/32726642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2020.110950
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