Hypoxia regulates GR function through multiple mechanisms involving microRNAs 103 and 107

Glucocorticoids (Gcs) potently inhibit inflammation, and regulate liver energy metabolism, often acting in a hypoxic environment. We now show hypoxic conditions open a specific GR cistrome, and prevent access of GR to part of the normoxic GR cistrome. Motif analysis identified enrichment of KLF4 bin...

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Publicat a:Mol Cell Endocrinol
Autors principals: Yang, Nan, Berry, Andrew, Sauer, Carolin, Baxter, Matthew, Donaldson, Ian J., Forbes, Karen, Donn, Rachelle, Matthews, Laura, Ray, David
Format: Artigo
Idioma:Inglês
Publicat: North Holland Publishing 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646191/
https://ncbi.nlm.nih.gov/pubmed/32871225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2020.111007
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