Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes typically associated with underlying hematologic and rheumatic diseases, respectively. Familial HLH is associated with genetic cytotoxic impairment and thereby to excess...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Tsoukas, Paul, Rapp, Emily, Van Der Kraak, Lauren, Weiss, Eric S., Dang, Vinh, Schneider, Corinne, Klein, Edwin, Picarsic, Jennifer, Salcedo, Rosalba, Stewart, C. Andrew, Canna, Scott W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Immunobiology and Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645987/
https://ncbi.nlm.nih.gov/pubmed/32589707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003846
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