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Life-threatening NLRC4-associated hyperinflammation successfully treated with Interleukin-18 inhibition
NLRC4-inflammasome hyperactivity causes infantile-onset Macrophage Activation Syndrome and enterocolitis with extraordinary serum IL-18 elevation (NLRC4-MAS). Herein, we report a critically ill infant with severe, refractory NLRC4-MAS who showed sustained response to treatment with experimental IL-1...
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| Yayımlandı: | J Allergy Clin Immunol |
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| Asıl Yazarlar: | , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846100/ https://ncbi.nlm.nih.gov/pubmed/27876626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.10.022 |
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