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Blocking Interleukin-1 in Rheumatic Diseases: Its Initial Disappointments and Recent Successes in the Treatment of Autoinflammatory Diseases
The role of the potent proinflammatory cytokine IL-1 in disease could clinically be investigated with the development of the IL-1 blocking agent anakinra (Kineret®), a recombinant IL-1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved fo...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080043/ https://ncbi.nlm.nih.gov/pubmed/20074280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2009.05159.x |
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