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Female sex mitigates motor and behavioural phenotypes in TDP-43(Q331K) knock-in mice

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders. ALS is more commonly seen in men than women and the same may be the case for FTD. Preclinical models demonstrating sex-specific vulnerability may help to understand female resistance to...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Watkins, Jodie, Ghosh, Anshua, Keerie, Amy F. A., Alix, James J. P., Mead, Richard J., Sreedharan, Jemeen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645778/
https://ncbi.nlm.nih.gov/pubmed/33154447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76070-w
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