Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO) mice and a ASMD patient. High SM reduced expression of the eC...

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Publicado en:EMBO Mol Med
Autores principales: Bartoll, Adrián, Toledano‐Zaragoza, Ana, Casas, Josefina, Guzmán, Manuel, Schuchman, Edward H, Ledesma, María Dolores
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645369/
https://ncbi.nlm.nih.gov/pubmed/33016621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911776
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