Dual Inhibition of α/β-Hydrolase Domain 6 and Fatty Acid Amide Hydrolase Increases Endocannabinoid Levels in Neurons

Agonists at cannabinoid receptors, such as the phytocannabinoid Δ(9)-tetrahydrocannabinol, exert a remarkable array of therapeutic effects but are also associated with undesirable psychoactive side effects. Conversely, targeting enzymes that hydrolyze endocannabinoids (eCBs) allows for more precise...

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Main Authors: Marrs, William R., Horne, Eric A., Ortega-Gutierrez, Silvia, Cisneros, Jose Antonio, Xu, Cong, Lin, Yi Hsing, Muccioli, Giulio G., Lopez-Rodriguez, Maria L., Stella, Nephi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190680/
https://ncbi.nlm.nih.gov/pubmed/21665953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.202853
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