Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO) mice and a ASMD patient. High SM reduced expression of the eC...

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Bibliografski detalji
Izdano u:EMBO Mol Med
Glavni autori: Bartoll, Adrián, Toledano‐Zaragoza, Ana, Casas, Josefina, Guzmán, Manuel, Schuchman, Edward H, Ledesma, María Dolores
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645369/
https://ncbi.nlm.nih.gov/pubmed/33016621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911776
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