PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF‐κB signaling

The latent HIV‐1 reservoir is a major barrier to viral eradication. However, our understanding of how HIV‐1 establishes latency is incomplete. Here, by performing a genome‐wide CRISPR‐Cas9 knockout library screen, we identify phosphatidylethanolamine‐binding protein 1 (PEBP1), also known as Raf kina...

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Veröffentlicht in:EMBO Rep
Hauptverfasser: Yang, Xinyi, Wang, Yanan, Lu, Panpan, Shen, Yinzhong, Zhao, Xiaying, Zhu, Yuqi, Jiang, Zhengtao, Yang, He, Pan, Hanyu, Zhao, Lin, Zhong, Yangcheng, Wang, Jing, Liang, Zhiming, Shen, Xiaoting, Lu, Daru, Jiang, Shibo, Xu, Jianqing, Wu, Hao, Lu, Hongzhou, Jiang, Guochun, Zhu, Huanzhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645261/
https://ncbi.nlm.nih.gov/pubmed/32924251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949305
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