3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro

Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP). HS binding to AP could vary according to modifications of HS chains by different sulfotransferases. 3-O-sulfotrans...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Maïza, Auriane, Sidahmed-Adrar, Nazha, Michel, Patrick P., Carpentier, Gilles, Habert, Damien, Dalle, Carine, Redouane, Walid, Hamza, Magda, van Kuppevelt, TH, Ouidja, Mohand Ouidir, Courty, José, Chantepie, Sandrine, Papy-Garcia, Dulce, Stettler, Olivier
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644699/
https://ncbi.nlm.nih.gov/pubmed/33154448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76030-4
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