Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregates drives the progression of neurodegenerative diseases in a prion-like manner. This phenomenon is now well described in cell and animal models and involves the release of protein aggregates into the ex...

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Detalhes bibliográficos
Main Authors: Holmes, Brandon B., DeVos, Sarah L., Kfoury, Najla, Li, Mei, Jacks, Rachel, Yanamandra, Kiran, Ouidja, Mohand O., Brodsky, Frances M., Marasa, Jayne, Bagchi, Devika P., Kotzbauer, Paul T., Miller, Timothy M., Papy-Garcia, Dulce, Diamond, Marc I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746848/
https://ncbi.nlm.nih.gov/pubmed/23898162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301440110
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