Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregates drives the progression of neurodegenerative diseases in a prion-like manner. This phenomenon is now well described in cell and animal models and involves the release of protein aggregates into the ex...

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Hlavní autoři: Holmes, Brandon B., DeVos, Sarah L., Kfoury, Najla, Li, Mei, Jacks, Rachel, Yanamandra, Kiran, Ouidja, Mohand O., Brodsky, Frances M., Marasa, Jayne, Bagchi, Devika P., Kotzbauer, Paul T., Miller, Timothy M., Papy-Garcia, Dulce, Diamond, Marc I.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746848/
https://ncbi.nlm.nih.gov/pubmed/23898162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301440110
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