3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro

Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP). HS binding to AP could vary according to modifications of HS chains by different sulfotransferases. 3-O-sulfotrans...

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Publicado no:Sci Rep
Main Authors: Maïza, Auriane, Sidahmed-Adrar, Nazha, Michel, Patrick P., Carpentier, Gilles, Habert, Damien, Dalle, Carine, Redouane, Walid, Hamza, Magda, van Kuppevelt, TH, Ouidja, Mohand Ouidir, Courty, José, Chantepie, Sandrine, Papy-Garcia, Dulce, Stettler, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644699/
https://ncbi.nlm.nih.gov/pubmed/33154448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76030-4
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