ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

The underlying pathological mechanisms of glaucomatous trabecular meshwork (TM) damage and elevation of intraocular pressure (IOP) are poorly understood. Here, we report that the chronic endoplasmic reticulum (ER) stress-induced ATF4-CHOP-GADD34 pathway is activated in TM of human and mouse glaucoma...

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發表在:Nat Commun
Main Authors: Kasetti, Ramesh B., Patel, Pinkal D., Maddineni, Prabhavathi, Patil, Shruti, Kiehlbauch, Charles, Millar, J. Cameron, Searby, Charles C., Raghunathan, VijayKrishna, Sheffield, Val C., Zode, Gulab S.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644693/
https://ncbi.nlm.nih.gov/pubmed/33154371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19352-1
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