Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells

Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhib...

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Vydáno v:Hum Vaccin Immunother
Hlavní autoři: Thepmalee, Chutamas, Panya, Aussara, Sujjitjoon, Jatuporn, Sawasdee, Nunghathai, Poungvarin, Naravat, Junking, Mutita, Yenchitsomanus, Pa-Thai
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644170/
https://ncbi.nlm.nih.gov/pubmed/31976810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2019.1701913
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