Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells

Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhib...

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Bibliografiske detaljer
Udgivet i:Hum Vaccin Immunother
Main Authors: Thepmalee, Chutamas, Panya, Aussara, Sujjitjoon, Jatuporn, Sawasdee, Nunghathai, Poungvarin, Naravat, Junking, Mutita, Yenchitsomanus, Pa-Thai
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644170/
https://ncbi.nlm.nih.gov/pubmed/31976810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2019.1701913
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