Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells

Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in the suppression of dendritic cell (DC) function, leading to decreased immune responses of the effector CD4(+) and C...

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Dettagli Bibliografici
Pubblicato in:Hum Vaccin Immunother
Autori principali: Thepmalee, Chutamas, Panya, Aussara, Junking, Mutita, Chieochansin, Thaweesak, Yenchitsomanus, Pa-thai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037468/
https://ncbi.nlm.nih.gov/pubmed/29420117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2018.1431598
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