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Pan-cancer landscape of homologous recombination deficiency
Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD) that can discriminate BRCA1- and BRCA2-subtype...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7643118/ https://ncbi.nlm.nih.gov/pubmed/33149131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19406-4 |
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