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Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase

Enzymes are catalysts of biological processes. Significant insight into their catalytic mechanisms has been obtained by relating site-directed mutagenesis studies to kinetic activity assays. However, revealing the detailed relationship between structural modifications and functional changes remains...

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Detalhes bibliográficos
Publicado no:IUCrJ
Main Authors: Kim, Jin Kyun, Lee, Cheol, Lim, Seon Woo, Andring, Jacob T., Adhikari, Aniruddha, McKenna, Robert, Kim, Chae Un
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642793/
https://ncbi.nlm.nih.gov/pubmed/33209313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252520011008
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