Broadly Reactive Influenza Antibodies Are Not Limited by Germinal Center Competition with High-Affinity Antibodies

Enhancing the generation of broadly reactive antibodies against influenza A virus (IAV) is a pertinent goal toward developing a universal IAV vaccine. While antibodies that bind conserved IAV epitopes have been identified in humans, antibodies specific for the variable epitopes are much more prevale...

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Veröffentlicht in:mBio
Hauptverfasser: Keating, Rachael, Johnson, Jenny L., Brice, David C., Labombarde, Jocelyn G., Dent, Alexander L., McGargill, Maureen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642676/
https://ncbi.nlm.nih.gov/pubmed/33144374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01859-20
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