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Reconstitution of rat fetal testis during the masculinisation programming window induces focal dysgenesis consistent with testicular dysgenesis syndrome

Focal dysgenesis is a consistent feature of testicular dysgenesis syndrome (TDS) in humans. Rodent studies show that perturbation of androgens (e.g. following phthalate exposure) during a fetal masculinisation programming window (MPW) predisposes to a TDS phenotype. This study aimed to determine whe...

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Vydáno v:Sci Rep
Hlavní autoři: Smart, Ellie, Macdonald, Joni, Smith, Lee B., Mitchell, Rod T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642428/
https://ncbi.nlm.nih.gov/pubmed/33149175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75803-1
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