DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

STUDY QUESTION: Does loss of DMRT1 in human fetal testis alter testicular development and result in testicular dysgenesis? SUMMARY ANSWER: DMRT1 repression in human fetal testis alters the expression of key testicular and ovarian determining genes, and leads to focal testicular dysgenesis. WHAT IS K...

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Detalhes bibliográficos
Publicado no:Hum Reprod
Main Authors: Macdonald, Joni, Kilcoyne, Karen R, Sharpe, Richard M, Kavanagh, Áine, Anderson, Richard A, Brown, Pamela, Smith, Lee B, Jørgensen, Anne, Mitchell, Rod T
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195803/
https://ncbi.nlm.nih.gov/pubmed/30272154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dey289
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