Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy

Oncogenic activation of the mTOR signaling pathway occurs frequently in tumor cells and contributes to the devastating features of cancer, including breast cancer. mTOR inhibitors rapalogs are promising anticancer agents in clinical trials; however, rapalogs resistance remains an unresolved clinical...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Guan, Yidi, Jiang, Shilong, Ye, Wenling, Ren, Xingcong, Wang, Xinluan, Zhang, Yi, Yin, Mingzhu, Wang, Kuansong, Tao, Yongguang, Yang, JinMing, Cao, Dongsheng, Cheng, Yan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642277/
https://ncbi.nlm.nih.gov/pubmed/33144562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03153-x
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk