Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy

Oncogenic activation of the mTOR signaling pathway occurs frequently in tumor cells and contributes to the devastating features of cancer, including breast cancer. mTOR inhibitors rapalogs are promising anticancer agents in clinical trials; however, rapalogs resistance remains an unresolved clinical...

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Publicado en:Cell Death Dis
Main Authors: Guan, Yidi, Jiang, Shilong, Ye, Wenling, Ren, Xingcong, Wang, Xinluan, Zhang, Yi, Yin, Mingzhu, Wang, Kuansong, Tao, Yongguang, Yang, JinMing, Cao, Dongsheng, Cheng, Yan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642277/
https://ncbi.nlm.nih.gov/pubmed/33144562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03153-x
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