Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma

AIM: Our previous research showed that AKT inactivation via small molecule inhibitors did not induce significant apoptosis, but rather markedly increased autophagy in nasopharyngeal carcinoma (NPC). The purpose of the current study was to determine whether autophagy inhibition can enhance the antica...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Zhao, Yuan-yuan, Tian, Ying, Liu, Lin, Zhan, Jian-hua, Hou, Xue, Chen, Xi, Zhou, Ting, Huang, Yan, Zhang, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2018
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120571/
https://ncbi.nlm.nih.gov/pubmed/30214154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S169952
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