Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma

AIM: Our previous research showed that AKT inactivation via small molecule inhibitors did not induce significant apoptosis, but rather markedly increased autophagy in nasopharyngeal carcinoma (NPC). The purpose of the current study was to determine whether autophagy inhibition can enhance the antica...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Zhao, Yuan-yuan, Tian, Ying, Liu, Lin, Zhan, Jian-hua, Hou, Xue, Chen, Xi, Zhou, Ting, Huang, Yan, Zhang, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120571/
https://ncbi.nlm.nih.gov/pubmed/30214154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S169952
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