RAD-Deficient Human Cardiomyocytes Develop Hypertrophic Cardiomyopathy Phenotypes Due to Calcium Dysregulation

Ras associated with diabetes (RAD) is a membrane protein that acts as a calcium channel regulator by interacting with cardiac L-type Ca(2 +) channels (LTCC). RAD defects can disrupt intracellular calcium dynamics and lead to cardiac hypertrophy. However, due to the lack of reliable human disease mod...

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Udgivet i:Front Cell Dev Biol
Main Authors: Li, Ya’nan, Chang, Yun, Li, Xiaolei, Li, Xiaowei, Gao, Jian, Zhou, Yafei, Wu, Fujian, Bai, Rui, Dong, Tao, Ma, Shuhong, Zhang, Siyao, Lu, Wen-Jing, Tan, Xiaoqiu, Wang, Yongming, Lan, Feng
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642210/
https://ncbi.nlm.nih.gov/pubmed/33195237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.585879
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