MLP-deficient human pluripotent stem cell derived cardiomyocytes develop hypertrophic cardiomyopathy and heart failure phenotypes due to abnormal calcium handling

Muscle LIM protein (MLP, CSRP3) is a key regulator of striated muscle function, and its mutations can lead to both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in patients. However, due to lack of human models, mechanisms underlining the pathogenesis of MLP defects remain uncle...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Cell Death Dis
Главные авторы: Li, Xiaowei, Lu, Wen-Jing, Li, Ya’nan, Wu, Fujian, Bai, Rui, Ma, Shuhong, Dong, Tao, Zhang, Hongjia, Lee, Andrew S., Wang, Yongming, Lan, Feng
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690906/
https://ncbi.nlm.nih.gov/pubmed/31406109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1826-4
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы