Epigenetic control of Cdkn2a.Arf protects tumor-infiltrating lymphocytes from metabolic exhaustion

T cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysfunctional. Environmental...

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Pubblicato in:Cancer Res
Autori principali: Koss, Brian, Shields, Bradley D., Taylor, Erin M., Storey, Aaron J., Byrum, Stephanie D., Gies, Allen J., Washam, Charity L., Choudhury, Samrat Roy, Ahn, Jeong Hyun, Uryu, Hidetaka, Williams, Jason B., Krager, Kimberly J., Chiang, Tung-Chin, Mackintosh, Samuel G., Edmondson, Rick D., Aykin-Burns, Nukhet, Gajewski, Thomas F., Wang, Gang Greg, Tackett, Alan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642172/
https://ncbi.nlm.nih.gov/pubmed/33004350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0524
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