A DNA-launched nanoparticle vaccine elicits CD8(+) T-cell immunity to promote in vivo tumor control

Cytolytic T cells (CTLs) play a pivotal role in surveillance against tumors. Induction of CTL responses by vaccination may be challenging, as it requires direct transduction of target cells or special adjuvants to promote cross-presentation. Here, we observed induction of robust CTL responses throug...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Res
Main Authors: Xu, Ziyang, Chokkalingam, Neethu, Tello-Ruiz, Edgar, Wise, Megan C., Bah, Mamadou A., Walker, Susanne, Tursi, Nicholas J., Fisher, Paul D., Schultheis, Katherine, Broderick, Kate E., Humeau, Laurent, Kulp, Daniel W., Weiner, David B.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642117/
https://ncbi.nlm.nih.gov/pubmed/32913042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0061
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