Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype

Despite the clinical success of T cell checkpoint blockade, most cancer patients still fail to have durable responses to immunotherapy. The molecular mechanisms driving checkpoint blockade resistance, whether pre-existing or evolved, remain unclear. To address this critical knowledge gap, we treated...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Jaiswal, Ashvin R., Liu, Arthur J., Pudakalakatti, Shivanand, Dutta, Prasanta, Jayaprakash, Priyamvada, Bartkowiak, Todd, Ager, Casey R., Wang, Zhi-Qiang, Reuben, Alexandre, Cooper, Zachary A., Ivan, Cristina, Ju, Zhenlin, Nwajei, Felix, Wang, Jing, Davies, Michael A, Davis, R. Eric, Wargo, Jennifer A., Bhattacharya, Pratip K, Hong, David S., Curran, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642111/
https://ncbi.nlm.nih.gov/pubmed/32917656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0005
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