Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the context of CTLA-4 and PD-1 blockade. We demonstr...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Jayaprakash, Priyamvada, Ai, Midan, Liu, Arthur, Budhani, Pratha, Bartkowiak, Todd, Sheng, Jie, Ager, Casey, Nicholas, Courtney, Jaiswal, Ashvin R., Sun, Yanqiu, Shah, Krishna, Balasubramanyam, Sadhana, Li, Nan, Wang, Guocan, Ning, Jing, Zal, Anna, Zal, Tomasz, Curran, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205399/
https://ncbi.nlm.nih.gov/pubmed/30188869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96268
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