Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the context of CTLA-4 and PD-1 blockade. We demonstr...

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Pubblicato in:J Clin Invest
Autori principali: Jayaprakash, Priyamvada, Ai, Midan, Liu, Arthur, Budhani, Pratha, Bartkowiak, Todd, Sheng, Jie, Ager, Casey, Nicholas, Courtney, Jaiswal, Ashvin R., Sun, Yanqiu, Shah, Krishna, Balasubramanyam, Sadhana, Li, Nan, Wang, Guocan, Ning, Jing, Zal, Anna, Zal, Tomasz, Curran, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205399/
https://ncbi.nlm.nih.gov/pubmed/30188869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96268
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