Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the context of CTLA-4 and PD-1 blockade. We demonstr...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Clin Invest
المؤلفون الرئيسيون: Jayaprakash, Priyamvada, Ai, Midan, Liu, Arthur, Budhani, Pratha, Bartkowiak, Todd, Sheng, Jie, Ager, Casey, Nicholas, Courtney, Jaiswal, Ashvin R., Sun, Yanqiu, Shah, Krishna, Balasubramanyam, Sadhana, Li, Nan, Wang, Guocan, Ning, Jing, Zal, Anna, Zal, Tomasz, Curran, Michael A.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2018
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205399/
https://ncbi.nlm.nih.gov/pubmed/30188869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96268
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة