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Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the context of CTLA-4 and PD-1 blockade. We demonstr...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6205399/ https://ncbi.nlm.nih.gov/pubmed/30188869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96268 |
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