Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the context of CTLA-4 and PD-1 blockade. We demonstr...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Jayaprakash, Priyamvada, Ai, Midan, Liu, Arthur, Budhani, Pratha, Bartkowiak, Todd, Sheng, Jie, Ager, Casey, Nicholas, Courtney, Jaiswal, Ashvin R., Sun, Yanqiu, Shah, Krishna, Balasubramanyam, Sadhana, Li, Nan, Wang, Guocan, Ning, Jing, Zal, Anna, Zal, Tomasz, Curran, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205399/
https://ncbi.nlm.nih.gov/pubmed/30188869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96268
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