Sildenafil potentiates the therapeutic efficacy of docetaxel in advanced prostate cancer by stimulating NO-cGMP signaling

BACKGROUND: Docetaxel plays an indispensable role in the management of advanced prostate cancer (PCa). However, more than half of patients do not respond to docetaxel, and those good responders frequently experience significant cumulative toxicity, which limits its dose duration and intensity. Hence...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Muniyan, Sakthivel, Rachagani, Satyanarayana, Parte, Seema, Halder, Sushanta, Seshacharyulu, Parthasarathy, Kshirsagar, Prakash, Siddiqui, Jawed A., Vengoji, Raghupathy, Rauth, Sanchita, Islam, Ridwan, Mallya, Kavita, Datta, Kaustubh, Xi, Lei, Das, Anindita, Teply, Benjamin A., Kukreja, Rakesh C., Batra, Surinder K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642013/
https://ncbi.nlm.nih.gov/pubmed/32847934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1569
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