Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model

Pancreatic cancer (PC) is acquired postnatally; to mimic this scenario, we developed an inducible Kras(G12D); Ptf1a-CreER™ (iKC) mouse model, in which Kras is activated postnatally at week 16 upon tamoxifen (TAM) administration. Upon TAM treatment, iKC mice develop pancreatic intraepithelial neoplas...

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Foilsithe in:Biol Open
Main Authors: Mallya, Kavita, Haridas, Dhanya, Seshacharyulu, Parthasarathy, Pothuraju, Ramesh, Junker, Wade M., Krishn, Shiv Ram, Muniyan, Sakthivel, Vengoji, Raghupathy, Batra, Surinder K., Rachagani, Satyanarayana
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists Ltd 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502593/
https://ncbi.nlm.nih.gov/pubmed/32709695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.052878
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