Scutellarin Ameliorates Renal Injury via Increasing CCN1 Expression and Suppressing NLRP3 Inflammasome Activation in Hyperuricemic Mice

Considerable evidences have indicated that elevated uric acid (UA) was involved in renal tubular injury leading to hyperuricemic nephropathy (HN). Scutellarin is a biologically active flavonoid derived from the Chinese traditional herb Erigeron breviscapus Hand-Mazz, which has been widely used in th...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Li, Guozheng, Guan, Chen, Xu, Lingyu, Wang, Lin, Yang, Chengyu, Zhao, Long, Zhou, Bin, Luo, Congjuan, Luan, Hong, Jiang, Wei, Li, Chenyu, Xu, Yan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641948/
https://ncbi.nlm.nih.gov/pubmed/33192525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.584942
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