Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy

Transgenic T-cell receptor (TCR) adoptive cell therapies recognizing tumor antigens are associated with robust initial response rates, but frequent disease relapse. This usually occurs in the setting of poor long-term persistence of cells expressing the transgenic TCR, generated using murine stem ce...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Nowicki, Theodore S., Farrell, Colin, Morselli, Marco, Rubbi, Liudmilla, Campbell, Katie M., Macabali, Mignonette H., Berent-Maoz, Beata, Comin-Anduix, Begoña, Pellegrini, Matteo, Ribas, Antoni
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641915/
https://ncbi.nlm.nih.gov/pubmed/32699033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0300
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