Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition

Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosine to inosine in duplex RNA, a modification that exhibits a multitude of effects on RNA structure and function. Recent studies have identified ADAR1 as a potential cancer therapeutic target. ADARs are also important in the de...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Thuy-Boun, Alexander S, Thomas, Justin M, Grajo, Herra L, Palumbo, Cody M, Park, SeHee, Nguyen, Luan T, Fisher, Andrew J, Beal, Peter A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641318/
https://ncbi.nlm.nih.gov/pubmed/32597966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa532
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