Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage

The splicing of tRNA introns is a critical step in pre-tRNA maturation. In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryotic TSEN is comprised of four core subunits (TSEN54, TSEN2, TSEN34 and TSEN15). The human TSEN complex addition...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Hayne, Cassandra K, Schmidt, Casey A, Haque, Maira I, Matera, A Gregory, Stanley, Robin E
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
NAR Breakthrough Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641302/
https://ncbi.nlm.nih.gov/pubmed/32476018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa438
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