Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

RATIONALE: Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully assessed. OBJECTIVE: Using single-cell transcriptomics and chromatin accessibility, we gained a better understanding of the pathophysiology...

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Publicat a:Circ Res
Autors principals: Depuydt, Marie A.C., Prange, Koen H.M., Slenders, Lotte, Örd, Tiit, Elbersen, Danny, Boltjes, Arjan, de Jager, Saskia C.A., Asselbergs, Folkert W., de Borst, Gert J., Aavik, Einari, Lönnberg, Tapio, Lutgens, Esther, Glass, Christopher K., den Ruijter, Hester M., Kaikkonen, Minna U., Bot, Ilze, Slütter, Bram, van der Laan, Sander W., Yla-Herttuala, Seppo, Mokry, Michal, Kuiper, Johan, de Winther, Menno P.J., Pasterkamp, Gerard
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641189/
https://ncbi.nlm.nih.gov/pubmed/32981416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.316770
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