Less mechanical loading attenuates osteoarthritis by reducing cartilage degeneration, subchondral bone remodelling, secondary inflammation, and activation of NLRP3 inflammasome

AIMS: Osteoarthritis (OA) is a disabling joint disorder and mechanical loading is an important pathogenesis. This study aims to investigate the benefits of less mechanical loading created by intermittent tail suspension for knee OA. METHODS: A post-traumatic OA model was established in 20 rats (12 w...

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Veröffentlicht in:Bone Joint Res
Hauptverfasser: He, Zhennian, Nie, Pengfei, Lu, Jianli, Ling, Yong, Guo, Jian, Zhang, Bin, Hu, Jianghua, Liao, Jiawei, Gu, Jie, Dai, Bo, Feng, Zhiyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: The British Editorial Society of Bone & Joint Surgery 2020
Schlagworte:
Arthritis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7640939/
https://ncbi.nlm.nih.gov/pubmed/33399476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1302/2046-3758.910.BJR-2019-0368.R2
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