Increased hippocampal TrkA expression ameliorates cranial radiation-induced neurogenesis impairment and cognitive deficit via PI3K/AKT signaling

Cognitive deficit is one of the most serious complications of cranial radiotherapy of head and neck cancers. However, the underlying mechanism of this cognitive impairment remains unclear. In the present study, the role of tropomyosin receptor kinase A (TrkA) and its ligand neurotrophin nerve growth...

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Publicado en:Oncol Rep
Autores principales: Ji, Shengjun, Wu, Haohao, Ding, Xin, Chen, Qingqing, Jin, Xing, Yu, Jinming, Yang, Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2020
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7640353/
https://ncbi.nlm.nih.gov/pubmed/33125501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2020.7782
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