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An endosomal acid-regulatory feedback system rewires cytosolic cAMP metabolism and drives tumour progression
Although suppressed cAMP levels have been linked to cancer for nearly five decades, the molecular basis remains uncertain. Here, we identify endosomal pH as a novel regulator of cytosolic cAMP homeostasis and a promoter of transformed phenotypic traits in colorectal cancer (CRC). Combining experimen...
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| Publicado no: | Mol Cancer Res |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2024
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7617132/ https://ncbi.nlm.nih.gov/pubmed/38319300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-23-0606 |
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