An endosomal acid-regulatory feedback system rewires cytosolic cAMP metabolism and drives tumour progression

Although suppressed cAMP levels have been linked to cancer for nearly five decades, the molecular basis remains uncertain. Here, we identify endosomal pH as a novel regulator of cytosolic cAMP homeostasis and a promoter of transformed phenotypic traits in colorectal cancer (CRC). Combining experimen...

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Pubblicato in:Mol Cancer Res
Autori principali: Prasad, Hari, Mandal, Susmita, Mathew, John Kandam Kulathu, Cherukunnath, Aparna, Duddu, Atchuta Srinivas, Banerjee, Mallar, Ramani, Harini, Bhat, Ramray, Jolly, Mohit Kumar, Visweswariah, Sandhya S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2024
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617132/
https://ncbi.nlm.nih.gov/pubmed/38319300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-23-0606
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